Virica Biotech and Ginkgo Bioworks Announce Partnership to Accelerate AAV Gene Therapy Manufacturing

Virica Biotech will provide a panel of their cell enhancers for use in high-throughput AAV production screening for Ginkgo’s clients.
Ginkgo Bioworks will leverage their advanced screening platform for rapid testing of VSEs directly in clients’ cell lines.

Virica Biotech and Ginkgo Bioworks Announce Partnership to Accelerate AAV Gene Therapy Manufacturing

GINKGO BIOWORKS MEDIA:
press@ginkgobioworks.com

VIRICA BIOTECH MEDIA:
communications@viricabiotech.com

Ginkgo Bioworks, Inc. (“Ginkgo”) which is buil

ding the leading platform for cell programming and biosecurity, and Virica Biotech Inc. (“Virica”), a leading developer of enhancers for scaling of viral vectors as well as cell and gene therapies, today announced a strategic partnership to enhance each company’s adeno-associated virus (AAV) gene therapy manufacturing platforms. This collaboration aims to tackle one of the major barriers to the widespread adoption of AAV-based gene therapies: the high cost of manufacturing.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20241003931014/en/

A combined offering will leverage the advanced capabilities of Ginkgo's AAV Services for Gene Therapy and Virica's proprietary VSE™ enhancer platform to offer innovators services and products to enhance AAV production titers and quality to reduce production costs and make gene therapies more accessible to patients.

"Our collaboration with Virica Biotech aligns perfectly with Ginkgo’s mission to provide innovative solutions to the gene therapy industry,” said Narendra Maheshri, VP, Genetic Medicines, Ginkgo Bioworks. “We’re excited to combine our proprietary HEKMo cell line, along with our proprietary innovations in plasmid engineering, with the exciting addition of VSEs. By integrating our high-throughput screening capabilities with Virica’s proprietary VSEs, we are well-positioned to drive down the costs of AAV manufacturing and provide a unique one-stop solution to our partners.”

Virica Biotech, a pioneer in the development of small molecule enhancers known as Viral Sensitizers (VSE™s), will provide to Ginkgo a panel of VSEs for use in high-throughput AAV production screening for Ginkgo’s clients. Ginkgo's advanced screening platform allows for rapid testing of VSEs directly in clients’ cell lines, providing valuable insights into how these molecules will perform at larger scales. The synergistic impact of VSEs with cell line modifications, novel plasmid constructs, and optimal bioprocess will provide Ginkgo’s partners with a holistic solution to enhance AAV production efficiency.

"Partnering with Ginkgo allows us to expand our capacity by leveraging their advanced screening and manufacturing capabilities, which are critical for rapidly identifying the most effective combination of VSEs for AAV production,” said Jean-Simon Diallo, CEO of Virica Biotech. “This partnership will enhance our ability to bring high-impact VSE solutions to market faster and also reinforces our commitment to improving the accessibility of gene therapies worldwide."

Make AAV gene therapies more accessible. Learn more about Ginkgo AAV Services for Gene Therapy and how we can help you optimize your manufacturing processes here. Meet both Virica and Ginkgo teams at the Cell & Gene Meeting on the Mesa.

About Virica Biotech
Virica develops cell enhancers which optimize the manufacturing of viral vectors and cell and gene therapies, allowing developers to economically deploy their products at scale. Virica’s Viral Sensitizer (VSE™) platform reduces production inefficiencies caused by innate cellular defenses in manufacturing cells. Purpose formulated VSE™ combinations substantially increase manufacturing yields and reduce the cost of goods for a range of products, including vaccines, gene therapies, and cell therapies.
https://www.viricabiotech.com/

About Ginkgo Bioworks
Ginkgo Bioworks is the leading horizontal platform for cell programming, providing flexible, end-to-end services that solve challenges for organizations across diverse markets, from food and agriculture to pharmaceuticals to industrial and specialty chemicals. Ginkgo Biosecurity is building and deploying the next-generation infrastructure and technologies that global leaders need to predict, detect, and respond to a wide variety of biological threats. For more information, visit ginkgobioworks.com and ginkgobiosecurity.com, read our blog, or follow us on social media channels such as X (@Ginkgo and @Ginkgo_Biosec), Instagram (@GinkgoBioworks), Threads (@GinkgoBioworks), or LinkedIn.